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Brain Gate From Wikipedia, the free encyclopedia
BrainGate is a brain implant system built and previously owned by Cyberkinetics, currently under development and in clinical trials, designed to help those who have lost control of their limbs, or other bodily functions, such as patients with amyotrophic lateral sclerosis (ALS) or spinal cord injury. The Braingate technology and related Cyberkinetic’s assets are now owned by privately held Braingate, LLC. The sensor, which is implanted into the brain, monitors brain activity in the patient and converts the intention of the user into computer commands.
Technology
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Dummy unit illustrating the design
of a BrainGate interface
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In its current form, BrainGate consists of a sensor implanted in the brain and an external decoder device, which connects to some kind of prosthetic or other external object. The sensor uses 100 hair-thin electrodes that sense the electromagnetic signature of neurons firing in specific areas of the brain, for example, the area that controls arm movement. The sensor translates that activity into electrically charged signals, which are then sent to an external device and decoded in software. The decoder connects to and can use the brain signals to control an external device, such as a robotic arm, a computer cursor, or even a wheelchair. In essence, BrainGate allows a person to manipulate objects in the world using only the mind.
In addition to real-time analysis of neuron patterns to relay movement, the BrainGate array is also capable of recording electrical data for later analysis. A potential use of this feature would be for a neurologist to study seizure patterns in a patient with epilepsy.
BrainGate was originally developed by researchers in the Department of Neuroscience at Brown University in conjunction with bio-tech company Cyberkinetics, Inc.. Cyberkinetics later spun off the device manufacturing to Blackrock Microsystems, who now manufactures the sensors and the data acquisition hardware. The BrainGate Company purchased the intellectual property and related technology from Cyberkinetics and continues to own the intellectual property related to BrainGate.
Research and Experimental Results
The initial clinical trial of BrainGate, led by researchers at Massachusetts General Hospital, Brown University, and the Department of Veterans Affairs, ran from 2004 to 2006 and studied four patients with tetraplegia. The results, published in a 2006 article in the journal Nature, showed that a human with tetraplegia was able to control a cursor on a computer screen just by thinking, enabling him to open emails, and to operate devices such as a television. One participant, Matt Nagle, had a spinal cord injury, whilst another had advanced ALS.
In July 2009, a second clinical trial (dubbed "BrainGate2") was initiated by researchers at Massachusetts General Hospital, Brown University, and the Providence VA. In November 2011, researchers from the Stanford University Neural Prosthetics Translational Laboratory joined the trial as a second site. This trial is ongoing.
In May 2012, BrainGate researchers published a study in Nature demonstrating that two people paralyzed by brainstem stroke several years earlier were able to control robotic arms for reaching and grasping. One participant, Cathy Hutchinson, was able to use the arm to drink coffee from a bottle, the first time she was able to drink unaided in 15 years. This took place on site at The Boston Home in Dorchester, Massachusetts, a specialized residence where Ms. Hutchinson resided. The study included researchers at Brown University, the Department of Veterans Affairs, Massachusetts General Hospital, Harvard Medical School, and the German Aerospace Center.
Current Clinical Trials
- As of July 8, 2009, clinical trials are being conducted under the name "BrainGate2 Neural Interface System."
- As of May 18, 2012, Stanford University and Massachusetts General Hospital are actively recruiting participants for the ongoing BrainGate2 clinical trial.
- BrainGate team wins $1M prize in Israel
See also:
- Brain-computer interface - Describes human trials with BrainGate
- Simulated reality
See the full article:
Brain Gate From Wikipedia, the free encyclopedia
Brain Implant
From Wikipedia, the free encyclopedia
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Schematic of the "Utah" Electrode Array
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Brain implants, often referred to as neural implants, are technological devices that connect directly to a biological subject's brain - usually placed on the surface of the brain, or attached to the brain's cortex. A common purpose of modern brain implants and the focus of much current research is establishing a biomedical prosthesis circumventing areas in the brain that have become dysfunctional after a stroke or other head injuries. This includes sensory substitution, e.g., in vision. Other brain implants are used in animal experiments simply to record brain activity for scientific reasons. Some brain implants involve creating interfaces between neural systems and computer chips. This work is part of a wider research field called brain-computer interfaces. (Brain-computer interface research also includes technology such as EEG arrays that allow interface between mind and machine but do not require direct implantation of a device.)
Neural-implants such as deep brain stimulation and Vagus nerve stimulation are increasingly becoming routine for patients with Parkinson's disease and clinical depression respectively, proving themselves as a boon for people with diseases which were previously regarded as incurable.
Purpose
Brain implants electrically stimulate, block or record (or both record and stimulate simultaneously) signals from single neurons or groups of neurons (biological neural networks) in the brain. The blocking technique is called intra-abdominal vagal blocking. This can only be done where the functional associations of these neurons are approximately known. Because of the complexity of neural processing and the lack of access to action potential related signals using neuroimaging techniques, the application of brain implants has been seriously limited until recent advances in neurophysiology and computer processing power.
Research
Research in sensory substitution has made progress in recent years. Especially in vision, due to the knowledge of the working of the visual system, eye implants (often involving some brain implants or monitoring) have been applied with demonstrated success. For hearing, cochlear implants are used to stimulate the auditory nerve directly. The vestibulocochlear nerve is part of the peripheral nervous system, but the interface is similar to that of true brain implants.
Multiple projects have demonstrated success at recording from the brains of animals for long periods of time. As early as 1976, researchers at the NIH led by Edward Schmidt made action potential recordings of signals from Rhesus monkey motor cortexes using immovable "hatpin" electrodes, including recording from single neurons for over 30 days, and consistent recordings for greater than three years from the best electrodes.
The "hatpin" electrodes were made of pure iridium and insulated with Parylene-c, materials that are currently used in the Cyberkinetics implementation of the Utah array. These same electrodes, or derivations thereof using the same biocompatible electrode materials, are currently used in visual prosthetics laboratories, laboratories studying the neural basis of learning, and motor prosthetics approaches other than the Cyberkinetics probes.
A competing series of electrodes and projects is sold by Plexon including Plextrode Series of Electrodes. These are variously the "Michigan Probes", the microwire arrays first used at MIT, and the FMAs from MicroProbe that emerged from the visual prosthetic project collaboration between Phil Troyk, David Bradley, and Martin Bak.
Other laboratory groups produce their own implants to provide unique capabilities not available from the commercial products.
Breakthroughs include studies of the process of functional brain re-wiring throughout the learning of a sensory discrimination, control of physical devices by rat brains, monkeys over robotic arms, remote control of mechanical devices by monkeys and humans, remote control over the movements of roaches, electronic-based neuron transistors for leeches, the first reported use of the Utah Array in a human for bidirectional signalling. Currently a number of groups are conducting preliminary motor prosthetic implants in humans. These studies are presently limited to several months by the longevity of the implants.
Much research is also being done on the surface chemistry of neural implants in effort to design products which minimize all negative effects that an active implant can have on the brain, and that the body can have on the function of the implant.
Another type of neural implant that is being experimented on is Prosthetic Neuronal Memory Silicon Chips, which imitate the signal processing done by functioning neurons that allows peoples' brains to create long-term memories.
Rehabilitation
See also: Nanotechnology and NeurotechnologyBrain pacemakers have been in use since 1997 to ease the symptoms of such diseases as epilepsy, Parkinson's Disease, dystonia and recently depression.
Current brain implants are made from a variety of materials such as tungsten, silicon, platinum-iridium, or even stainless steel. Future brain implants may make use of more exotic materials such as nanoscale carbon fibers (nanotubes), and polycarbonate urethane.
Historical Research on Brain Implants
See also: History of neuroimagingIn 1870, Eduard Hitzig and Gustav Fritsch demonstrated that electrical stimulation of the brains of dogs could produce movements. Robert Bartholow showed the same to be true for humans in 1874. By the start of the 20th century, Fedor Krause began to systematically map human brain areas, using patients that had undergone brain surgery.
Prominent research was conducted in the 1950s. Robert G. Heath experimented with aggressive mental patients, aiming to influence his subjects' moods through electrical stimulation.
Yale University physiologist Jose Delgado demonstrated limited control of animal and human subjects' behaviours using electronic stimulation. He invented the stimoceiver or transdermal stimulator, a device implanted in the brain to transmit electrical impulses that modify basic behaviours such as aggression or sensations of pleasure.
Delgado was later to write a popular book on mind control, called Physical Control of the Mind, where he stated: "the feasibility of remote control of activities in several species of animals has been demonstrated [...] The ultimate objective of this research is to provide an understanding of the mechanisms involved in the directional control of animals and to provide practical systems suitable for human application."
In the 1950s, the CIA also funded research into mind control techniques, through programs such as MKULTRA. Perhaps because he received funding for some research through the US Office of Naval Research, it has been suggested (but not proven) that Delgado also received backing through the CIA. He denied this claim in a 2005 article in Scientific American describing it only as a speculation by conspiracy-theorists. He stated that his research was only progressively scientifically-motivated to understand how the brain works.
Ethical Considerations
Who are good candidates to receive neural implants? What are the good uses of neural implants and what are the bad uses? Whilst deep brain stimulation is increasingly becoming routine for patients with Parkinson's disease, there may be some behavioural side effects. Reports in the literature describe the possibility of apathy, hallucinations, compulsive gambling, hypersexuality, cognitive dysfunction, and depression. However, these may be temporary and related to correct placement and calibration of the stimulator and so are potentially reversible.
Some transhumanists, such as Raymond Kurzweil and Kevin Warwick, see brain implants as part of a next step for humans in progress and evolution, whereas others, especially bioconservatives, view them as unnatural, with humankind losing essential human qualities. It raises controversy similar to other forms of human enhancement. For instance, it is argued that implants would technically change people into cybernetic organisms (cyborgs). It's also given that all research is to comply to the Helsinki-declaration. Yet further, the usual legal duties apply such as information to the person wearing implants and that the implants are voluntary, with (very) few exceptions.
Brain Implants in Fiction and Philosophy
Brain implants are now part of modern culture but there were early philosophical references of relevance as far back as René Descartes.
In his 1638 Discourse on the Method, a study on proving self existence, Descartes wrote that a person would not know if an evil demon had trapped his mind in a black box and was controlling all inputs and outputs. Philosopher Hilary Putnam provided a modern parallel of Descartes argument in his 1989 discussion of a brain in a vat, where he argues that brains which were directly fed with an input from a computer would not know the deception from reality.
Popular science fiction discussing brain implants and mind control became widespread in the 20th century, often with a dystopian outlook. Literature in the 1970s delved into the topic, including The Terminal Man by Michael Crichton, where a man suffering from brain damage receives an experimental surgical brain implant designed to prevent seizures, which he abuses by triggering for pleasure.
Fear that the technology will be misused by the government and military is an early theme. In the 1981 BBC serial The Nightmare Man the pilot of a high-tech mini submarine is linked to his craft via a brain implant but becomes a savage killer after ripping out the implant.
Perhaps the most influential novel exploring the world of brain implants was William Gibson's 1984 novel Neuromancer. This was the first novel in a genre that came to be known as "cyberpunk". It follows a computer hacker through a world where mercenaries are augmented with brain implants to enhance strength, vision, memory, etc. Gibson coins the term "matrix" and introduces the concept of "jacking in" with head electrodes or direct implants. He also explores possible entertainment applications of brain implants such as the "simstim" (simulated stimulation) which is a device used to record and playback experiences.
Gibson's work led to an explosion in popular culture references to brain implants. Its influences are felt, for example, in the 1989 roleplaying game Shadowrun, which borrowed his term "datajack" to describe a brain-computer interface. The implants in Gibson's novels and short stories formed the template for the 1995 film Johnny Mnemonic and later, The Matrix Trilogy.
The Gap Cycle (The Gap into): In Stephen R. Donaldson's series of novels, the use (and misuse) of "zone implant" technology is key to several plotlines.
Pulp fiction with implants or brain implants include the novel series Typers, film Spider-Man 2, the TV series Earth: Final Conflict, and numerous computer/video games.
Ghost in the Shell anime and manga franchise: Cyberbrain neural augmentation technology is the focus. Implants of powerful computers provide vastly increased memory capacity, total recall, as well as the ability to view his or her own memories on an external viewing device. Users can also initiate a telepathic conversation with other cyberbrain users, the downsides being cyberbrain hacking, malicious memory alteration, and the deliberate distortion of subjective reality and experience.
In the video games PlanetSide and Chrome, players can use implants to improve their aim, run faster, and see better, along with other enhancements.
The Deus Ex video games series addresses the nature and impact of human enhancement with regard to a wide variety of prosthesis and brain implants. Deus Ex: Human Revolution, set in 2027, details the impact on society of human augmentation and the controversy it could generate. Several characters in the game have implanted neurochips to aid their professions (or their whims). Examples are of a helicopter pilot with implanted chips to better pilot her aircraft and analyse flight paths, velocity and spatial awareness, as well as a hacker with a brain-computer interface that allows direct access to computer networks and also to act as a 'human proxy' to allow an individual in a remote location to control his actions. The game raises the question of the downsides of this kind of augmentation as those who cannot afford the enhancements (or object to getting them) rapidly find themselves at a serious disadvantage against people with artificial enhancement of their abilities. The spectre of being forced to have mechanical or electronic enhancements just to get a job is explored as well. The storyline addresses the effect of implant rejection by use of the fictional drug 'Neuropozyne' which breaks down glial tissue and is also fiercely addictive, leaving people who have augmentations little choice but to continue buying the drug from biotech corporations who control the price of it. Without the drug, augmented people experience rejection of implants, crippling pain and possible death.
Film
Brainstorm (1983): The military tries to take control over a new technology that can record and transfer thoughts, feelings, and sensations.
Johnny Mnemonic (1995): The main character acts as a "mnemonic courier" by way of a storage implant in his brain, allowing him to carry sensitive information undetected between parties.
The Manchurian Candidate (2004): For a means of mind control, the presidential hopeful Raymond Shaw unknowingly has a chip implanted in his head by Manchurian Global, a fictional geopolitical organization aimed at making parts of the government sleeper cells, or puppets for their monetary advancement.
Hardwired (2009): A corporation attempting to bring marketing to the next level implants a chip into main character's brain.
The extreme box office success of the Matrix films, combined with earlier science fiction references, have made brain implants ubiquitous in popular literature.
Television
Blake's 7: Oleg Gan, a character, has a brain implant which is supposed to prevent future aggression after being convicted of killing an officer from the oppressive Federation.
Dark Angel: The notorious Red Series use neuro-implants pushed into their brain stem at the base of their skull to amp them up and hyper-adrenalize them and make them almost unstoppable. Unfortunately the effects of the implant burn out their system between six months to a year and kill them.
The X-Files (episode:Duane Barry, relevant to the overreaching mytharc of the series.): FBI Agent Dana Scully discovers an implant set under the skin at the back of her neck which can read her every thought and change memory through electrical signals that alter the brain chemistry.
Star Trek franchise: Members of the Borg collective are equipped with brain implants which connect them to the Borg collective consciousness.
Fringe: The Observers use a needle like, self-guided implant which allows them to read the minds of others at the expense of emotion. The implant also allows for short range teleportation and increases intelligence.
See also: Category: Brain–computer interfacing in fiction
See also:
- Auditory brainstem implant (ABI)
- History of neuroimaging
- Nanotechnology
- Neurotechnology
- Transhumanism
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