Dr. Ramachandran hypothesized that every time the patient attempted to move the paralyzed limb, they received sensory feedback (vision and proprioception) that the limb did not move. This feedback stamped itself into the brain so the brain had learned that the limb was paralyzed. A mirror box is used to eliminate the learned paralysis.
The visual feedback that mirror therapy provides replaces the sensory feedback that the brain expects from the affected limb. It has been suggested that visualizing and undertaking symmetrical bilateral movements post stroke enhance neuroplastic changes within the brain.
For more information look at YouTube: Mirror Box therapy and look at the Wikipedia article: Mirror Box
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